PHYTOCHEMICAL ANALYSIS AND ANTIHYPERTENSIVE PROPERTIES OF ETHYL ACETATE EXTRACT OF TAPINANTHUS DODONEIFOLIUS
Abstract
The study aimed to explore the phytochemical composition and antihypertensive properties of the ethyl acetate extract of Tapinanthus dodoneifolius, a parasitic plant traditionally used in folk medicine. Phytochemical analysis of the ethyl acetate extract revealed the presence of various bioactive compounds, including alkaloids, flavonoids, tannins, saponins, and glycosides, which are known for their therapeutic potentials. The antihypertensive effect was evaluated through in vitro and in vivo assays, focusing on the plant extract's ability to modulate blood pressure in hypertensive animal models. The results demonstrated a significant reduction in systolic and diastolic blood pressure, suggesting a potential mechanism involving vasodilation, inhibition of angiotensin-converting enzyme (ACE), and improvement of endothelial function. These findings provide scientific validation for the traditional use of Tapinanthus dodoneifolius in the management of hypertension. Further studies are warranted to isolate the active compounds and elucidate the precise molecular pathways involved in its antihypertensive activity. This research opens new avenues for developing natural antihypertensive therapies based on Tapinanthus dodoneifolius.
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