EFFECTS OF BETA-CARYOPHYLLENE FROM PIPER GUINEENSE FRUITS ON SOME HEMATOLOGICAL PARAMETERS IN OXALIPLATIN TREATED WISTAR RAT
Abstract
This study investigate the potential protective effects of beta- caryophyllene from Piper Guinness fruits on some Hematology Parameters in Oxaliplatin treated wistar rat. Oxaliplatin, a platinum-based chemotherapeutic agent, is widely used to treat colorectal cancer. Its efficacy is attributed to its ability to induce DNA damage, leading to cancer cell death. However, oxaliplatin therapy is often associated with haematological toxicity, neurotoxicity, and gastrointestinal side effects. Despite these limitations, oxaliplatin remains a crucial component of colorectal cancer treatment regimens, improving patient outcomes and survival rates. Ongoing research aims to mitigate its toxic effects and enhance its therapeutic potential.Investigates the protective effects of beta-caryophyllene (BCP) on hematological parameters in Wistar rats undergoing oxaliplatin treatment. Beta-caryophyllene, a component of Piper guineense, is known for its anti-inflammatory and pharmacological properties. The research aims to assess whether BCP can mitigate the hematological toxicity typically induced by oxaliplatin, a chemotherapeutic agent. The study's findings suggest that BCP administration may help preserve blood parameters such as red blood cell count, white blood cell count, hemoglobin levels, and platelet count, thereby offering potential supportive benefits during chemotherapy .
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