PROTECTIVE EFFECT OF ETHANOL FRUIT EXTRACT OF C. ALBIDUM ON LEAD INDUCED NEUROPATHY IN WISTAR RATS
Abstract
Heavy metal neurotoxicity, especially that caused by lead, continues to be an important issue in public health due to its adverse effects on the central nervous system. This study investigates the neuroprotective effect of Chrysophyllum albidum (CA) extract on lead-induced neuropathology in Wistar rats. Rats weighing between 70g to 150g were divided into groups and exposed to lead acetate with and without administration of CA extract. Behavioral experiments, including Y-Maze test, Forced swim test (FST), Open field test (OFT), were conducted to evaluate antidepressant (SOD), catalase (CAT), glutathione (GSH), and malondialdehyde (MDA) were performed on brain tissue homogenates.
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