EFFECTS OF CEIBA PENTANDRA STEM EXTRACT ON HAEMATOLOGICAL PARAMETERS IN WISTAR RATS TREATED WITH MONOSODIUM GLUTAMATE

The study was done to ascertain the Effect of Ceiba Pentandra Stem Extract on Haematological Parameters in Wistar Rats treated with Monosodium Glutamate. Thirty (30) male wistar rats were assigned into five groups (n = 6). Group A rats were fed with standard rat pellet and water only throughout the period of experimentation (21 days). Group 1 rats were fed with standard rat pellet and water only. Group - Negative control (8000 mg/kg of MSG only. Group 3- CPSE (200 mg/kg) + 8000 mg/kg of MSG. Group 4- CPSE (400 mg/kg) + 8000 mg/kg of MSG. Group 5- CPSE (800 mg/kg) + 8000 mg/kg of MSG. CPSE had no acute toxicity. MSG decreased RBC count as a result of MSG inducing oxidative damage in various tissues, including blood cells, leading to increased lipid peroxidation and decreased antioxidant defense systems. This can cause hemolysis and a decrease in RBC count, thereby reducing their overall count and consequently decreasing PCV and Hb levels. CPSE contains various phytochemicals such as flavonoids, tannins, and saponins, which have strong antioxidant properties. These antioxidants scavenge reactive oxygen species (ROS) and reduce oxidative stress, protecting RBCs from oxidative damage and hemolysis. MSG exposure resulted in significant reductions in WBC counts which may have caused immunosuppressive actions and oxidative damage. The lack of significant differences in WBC among the CPSE-treated groups may be that CPSE quantity was insufficient to improve WBC count. MSG and CPSE did not alter PLT, MCV, MCH, and MCHC.