INVIVO NEMATOCIDAL ACTIVITIES OF CRUDE AQUEOUS INFUSION OF JATROPHA CURCAS AGAINST HELIGMOSOMOIDE BAKERI IN MICE
Abstract
THE AIM OF THIS STUDY WAS TO INVESTIGATE THE POTENTIAL NEMATOCIDAL ACTIVITIES OF A CRUDE AQUEOUS INFUSION OF JATROPHA CURCAS AGAINST HELIGMOSOMOIDE BAKERI IN MICE. THE EXPERIMENT INVOLVED ADMINISTERING THE INFUSION TO MICE INFECTED WITH H. BAKERI AND MONITORING ITS EFFECTS ON THE PARASITE. RESULTS SHOWED THAT THE CRUDE AQUEOUS INFUSION OF JATROPHA CURCAS EXHIBITED SIGNIFICANT NEMATOCIDAL ACTIVITY AGAINST H. BAKERI IN MICE. THE INFUSION WAS FOUND TO REDUCE THE WORM BURDEN AND EGG COUNT, INDICATING ITS EFFICACY IN CONTROLLING THE INFECTION. ADDITIONALLY, THE INFUSION DEMONSTRATED A DOSE-DEPENDENT EFFECT, WITH HIGHER DOSES RESULTING IN A GREATER REDUCTION IN WORM BURDEN AND EGG COUNT. THESE FINDINGS SUGGEST THAT THE CRUDE AQUEOUS INFUSION OF JATROPHA CURCAS HAS POTENTIAL AS A NATURAL NEMATOCIDAL AGENT AGAINST H. BAKERI INFECTIONS. FURTHER STUDIES ARE NEEDED TO ELUCIDATE THE UNDERLYING MECHANISMS OF ACTION AND TO EVALUATE ITS SAFETY AND EFFICACY IN OTHER ANIMAL MODELS AND POTENTIALLY IN HUMANS. OVERALL, THIS RESEARCH HIGHLIGHTS THE POTENTIAL OF JATROPHA CURCAS AS A NATURAL ALTERNATIVE FOR THE TREATMENT OF HELMINTH INFECTIONS.
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