EFFECT OF ETHANOLIC STEM BARK EXTRACT OF ZANTHOXYLUM RHETSA LOW DOSE ON THE LIVER FUNCTION PARAMETERS ON ALBINO RATS
Abstract
This study evaluated the effect of ethanolic stem bark extract of Zuntharyltun Mesa high dace on the liver and renal function parameters albino rats. Acute toxicity was determined in rats by oral administration of single dose of up to 5000 mg/kg of the ethanolic stem bark extract of at:chary:um the The experimental rats were randomly grouped into three (3) groups of 5 rats each Group I served as normal control. group 2 received 600mg/kg. group 3 received 1300ingilig. After 14 days of oral administration of the extract, the rats were smirked and blood collected. The liver function parameters were then examined. In acute toxicity study. no signs of toxicity or death were recorded. All animals were allowed to feed and water ad libitum. After 14 days of oral administration of the extract, the animals were sacrificed and blood collected. In acute toxicity study, no signs of toxicity or death were recorded. The result of the 1.1))0 showed that the plant is not toxic even at a dose of 5000mg/kg. This study showed a significant (p
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