ACUTE TOXICITY STUDY OF AQUEOUS LEAF EXTRACT OF MELIA AZEDARACH (CHINABERRY)
Abstract
The acute toxicity study of the aqueous leaf extract of Meliaazedarach (Chinaberry) was conducted to evaluate its toxicological effects and identify a safe dosage range. Meliaazedarach, a tree with established traditional medicinal uses, also contains toxic components, particularly in its fruits and seeds. This study employed adult female albino rats following OECD guideline 425 (Up-and-Down Procedure) for acute oral toxicity testing. Leaves ofMeliaazedarach were collected, shade-dried, and processed into an aqueous extract. The extract was administered in doses ranging from 1000 to 5000 mg/kg body weight. Observations for clinical signs, behavioral changes, and mortality were recorded over a 14-day period postadministration. Results indicated no toxic effect observed and no mortality was found which shows leaf extract are safe for medicinal use. The LD50 was estimated to establish a safe dosage threshold for potential medicinal applications. This study highlights the importance of toxicity assessments for traditional plant-based medicines and supports the safe therapeutic use ofMeliaazedarach within specified dose limits.
Full-Text Access Notice
In accordance with the NERD Policy on promoting peer-reviewed publication, public access to the full text of a project, thesis or dissertation is restricted for three years, allowing the author and supervisors sufficient time to pursue peer-reviewed publication.
During this period, researchers with legitimate academic or research purposes may request authorisation directly from the author to enable NERD to release the indexed full texts of the work using the form below.