EFFECT OF GARLIC OIL ON CHEMICAL NOCICEPTION AND REDUCED GLUTATHIONE (GSH) IN PACLITAXEL INDUCED PERIPHERAL, NEUROPATIC PAIN IN DROSOPHILA MELANOGASTER FLIES.
Abstract
ABSTRACT
Peripheral neuropathy is a common and dose-limiting side effect of the chemotherapeutic agent
paclitaxel, often characterized by nociceptive hypersensitivity and oxidative stress. Drosophila
melanogaster, a genetically tractable model organism, has been widely used to study nociceptive
mechanisms and neuroprotection. Garlic oil, known for its antioxidant and anti-inflammatory
properties, presents a potential therapeutic intervention.
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