DETERMINATION OF THE ACUTE EFFECT OF LEAD NITRATE EXPOSURE ON ELECTROLYTE PROFILE IN MALE ALBINO WISTAR RATS TREATED WITH ETHANOL LEAVE EXTRACTS OF GONGRONEMA LATIFOLIUIM AND MORINGA OLEIFERA
Abstract
Acute impact of lead nitrate exposure on electrolute profile in male albino wistar rats treated with ethanolic leave extacts of G. latifolium and M. oleifera was determined. Twenty (20) animals weighing 94.25-125.50g were randomly grouped into five groups of four rats each. Groups 1 - 4 were exposed orally to 30% below the LD50 of lead nitrate [Pb(NO3)2] before treatment. Groups 1 and 2 were later treated with 500mg/kg ethanol leave extracts of G. latifolium and M. oleifera respectively. Group 3 was treated with 500mg/kg of the two leave extracts at 50:50 dosage ratio. Groups 4 and 5 were not treated and served as positive and normal control groups respectively. The treatment was done daily via oral route for 14 days and the animals were fed with commercial rat mash and water throughout the period of treatment. At the end of the experiment, no significant difference (P>0.05) was observed in serum bicarbonoic (HCO3-), sodium (Na+), Potassium (K+) and chloride (Cl-) ions levels between groups of animals. A non-significant increase (P>0.05) in serum HCO3- level in the positive control group (group 4) was observed when compared to group 1, 2, 3 and normal control group (group 5). A non-significant decrease (P>0.05) in serum HCO3- and Cl- levels were found in group 5 when compared to groups 1, 2, 3 and positive control group. A non-significant increase (P>0.05) in serum HCO3- and Na+ levels in groups 1 and 5 when compared to groups 2, 3 and 4. Serum K+ showed a non-significant increased (P>0.05) in groups 2 and 5 when compared to groups 1, 3 and 4 respectively. The results of these findings implied that though there was no significant difference in serum HCO3-, Na+, K+, and Cl- levels in the study animals, lead nitrate impacted certain level of toxic influence on the electrolyte profile which might have been ameliorated by the efficacy of the ethanol leaves extracts treatment on the animals.
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