DETERMINATION OF ANTIBACTERIAL ACTIVITY OF COMMIPHORA AFRICANA AGAINST CLINICAL ISOLATE STAPHYLOCOCCUS AUREUS AND E. COLI ASSOCIATED WITH SOME INFECTED WOUND.
Abstract
Abstract
Wound infections caused by Staphylococcus aureus and Escherichia coli pose significant health challenges, often leading to complications due to antibiotic resistance. This study investigates the antibacterial activity of Commiphora africana extracts against clinical isolates of S. aureus and E. coli obtained from infected wounds. Ethanolic and aqueous extracts of C. africana were prepared and screened for antibacterial efficacy using the agar well diffusion method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were also determined. Results revealed that C. africana exhibited notable antibacterial activity against both pathogens, with the ethanolic extract demonstrating higher inhibition zones compared to the aqueous extract. The MIC and MBC values confirmed the potential of C. africana as a natural antimicrobial agent. These findings suggest that Commiphora africana could serve as an alternative or complementary treatment for bacterial wound infections,
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