EFFECTS OF CHRONIC ASPARTAME INTAKE ON WEIGHT, AND BLOOD SUGAR LEVEL IN FEMALE WISTAR RAT

Abstract This study investigated the effects of chronic aspartame intake on body weight and blood glucose levels in female Wistar rats. Aspartame, a widely used artificial sweetener, is commonly consumed as a sugar substitute, yet its long-term metabolic effects remain a subject of scientific concern. In this experimental study, healthy female Wistar rats were randomly assigned into control and treatment groups. The treatment groups received varying doses of aspartame orally over a prolonged period, while the control group was maintained on a standard diet without aspartame supplementation. Body weight measurements were recorded weekly, and blood glucose levels were assessed at baseline and at regular intervals during the study period using standard biochemical methods. The results indicated that chronic aspartame intake produced dose-dependent changes in body weight, with some groups showing significant weight gain or reduction compared to the control. Additionally, alterations in blood glucose levels were observed, suggesting possible effects on glucose metabolism and insulin sensitivity. The findings suggest that prolonged consumption of aspartame may influence body weight regulation and glycemic control in female Wistar rats. These outcomes highlight the need for cautious consumption of artificial sweeteners and further studies to elucidate the underlying mechanisms and potential implications for human health.