PREVALENCE OF RED CELL ALLOANTIBODIES IN MULTI-TRANSFUSED SUBJECTS WITH SICKLE CELL ANAEMIA IN MURTALA MUHAMMAD SPECIALIST HOSPITAL KANO
Abstract
Blood transfusion and its component has become an integral part of patient management in modern medicine and play a vital role in the management of patient with sign and symptom of hypoxia. The risk of alloimmunization is especially high in patient receiving multiple transfusion. The incident of alloimmunization is not uniform among all multiple transfused patients. The risk of development of red blood cell on the body depends on the age, sex, and genetic makeup of the patient as well as number and frequency of blood transfusion. The aim of this research is to assess alloantibodies in multiple transfused patients attending Murtala Muhammad Specialist Hospital, Kano Nigeria. A total of 79 male and female subjects were recruited in this study. The present of alloantibodies were detected using indirect comb test and ABO blood grouping using tube method. Out of 79 samples analyzed, 8 samples showed positive results during antibody screening, therefore the prevalence of red cell alloantibody among the multiply transfused patients was found to be 8.9%. Out of eight subjects that have alloantibodies, 50% were males while 50% were females. Our present study showed that the incident of alloimmunization is increased with increased number of blood transfusion. This current study shown that blood transfusion is the major causes of development of alloantibodies.
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