SYNTHESIS OF CU (II), CR (III), AND FE (III) COMPLEXES USING PARACETAMOL AS A LIGAND

This study investigates the synthesis and characterization of a copper (II)-paracetamol complex to explore its potential for enhancing the pharmacological properties of paracetamol, a widely used analgesic and antipyretic drug. Paracetamol, known for its phenolic and amide groups, serves as a bidentate ligand capable of forming coordination complexes with transition metals like copper. Copper(II) was chosen for its biological significance and ability to form stable complexes with organic ligands, potentially improving the drug's solubility, stability, and therapeutic efficacy. The synthesis was performed using a solvent-free grinding method, an eco-friendly approach that eliminates solvent use while ensuring optimal complex formation. The resulting copper-paracetamol complex was characterized by distinct physical and chemical properties, including a blue color and a melting point of 55°C, indicating successful coordination between the metal ion and the drug. The study underscores the advantages of metal-drug complexes in medicinal chemistry. By modifying paracetamol's pharmacokinetic and pharmacodynamic properties through copper coordination, the complex could offer enhanced therapeutic benefits, such as increased antioxidant activity and reduced hepatotoxicity. The findings align with ongoing research into metal-based drugs, which aim to address limitations of conventional pharmaceuticals by enhancing their efficacy and safety profiles. Recommendations include advanced characterization of the complex's structure, such as UV-Vis spectroscopy and X-ray crystallography, and evaluation of its antimicrobial and antioxidant properties. This research contributes to the development of innovative drug formulations, positioning metal-drug complexes as promising candidates for addressing global health challenges