ANTIDERMATOPHYTIC AND ANTIOXIDANT ACTIVITIES OF LIME PEEL ESSENTIAL OIL ON SELECTED DERMATOPHYTE

Abstract This study investigated the antidermatophytic and antioxidant activities of lime peel essential oil (LPEO) against selected dermatophytes, namely Microsporum canis, Epidermatophyton floccosum, and Trichophyton floccosum. The antifungal efficacy was evaluated through agar well diffusion, determining zones of inhibition, minimum inhibitory concentration (MIC), and minimum fungicidal concentration (MFC). Results showed that LPEO exhibited concentration-dependent antifungal activity against all test organisms, with notable zones of inhibition and effective MIC values indicating significant antifungal potential. Although LPEO demonstrated substantial antioxidant activity, it was comparatively lower than standard ascorbic acid. The findings affirm the potential of LPEO as a natural antifungal and antioxidant agent. These properties suggest possible applications in pharmaceutical formulations, particularly as alternatives to synthetic antifungal treatments and preservatives. The study recommends further exploration into the formulation of LPEO-based topical products like creams and ointments, coupled with toxicity and safety assessments to ensure suitability for long-term use. Comparative studies with conventional antifungal drugs are also encouraged to position LPEO within therapeutic and industrial contexts.