EFFECTS OF SLEEP DEPRIVATION ON GASTRIC ACID SECRETION IN THE HEALING PROCESS OF GASTRIC ULCER IN MALE WISTAR RATS
Abstract
ABSTRACT
Sleep deprivation (SD) is a physiological stressor known to disrupt gastrointestinal integrity and alter gastric secretory function. This study investigated the effect of sleep deprivation on gastric acid secretion during the healing process of acetic acid-induced gastric ulcers in male Wistar rats.
Sixty rats were assigned into four groups (n = 5): Control, Gastric Ulcer (GU), Sleep Deprived (SD), and Gastric Ulcer + Sleep Deprived (USD). Gastric ulcers were induced using the acetic acid method, while sleep deprivation was achieved by the gentle handling method (6 h/day) for 3, 7, and 14 consecutive days. At the end of each experimental period, gastric acid secretion was determined using the pylorus ligation method, and ulcer severity was scored macroscopically. Data were analyzed using one-way ANOVA with significance set at p < 0.05. Results showed a significant increase in gastric acid secretion and ulcer scores in GU and USD groups compared with the Control group on days 3 and 7, with the USD group exhibiting the highest values. By day 14, a general reduction in gastric acidity was observed in all groups; however, the USD group maintained significantly elevated acid secretion compared with GU and SD groups. These findings suggest that sleep deprivation delays gastric ulcer healing by sustaining hyperacidity during the recovery phase. These findings suggest that sleep deprivation delays ulcer healing by sustaining hyperacidity, highlighting the importance of proper sleep management.
Keywords: Sleep deprivation, gastric ulcer, gastric ulcer healing, oxidative stress, gastric acid secretion, acetic acid
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