EFFECT OF SODIUM ACETATE ON LIPID PROFILE IN STREPTOZOCIN INDUCED DIABETES MELLITUS IN MALE WISTAR RATS.
Abstract
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia and alterations in lipid metabolism. Dyslipidemia is a common complication of diabetes and contributes significantly to cardiovascular disease. This study evaluated the effect of sodium acetate on lipid profile parameters in streptozotocin-induced diabetic male Wistar rats. Twenty-four adult male Wistar rats were divided into four groups: normal control, diabetic control, diabetic treated with low-dose sodium acetate, and diabetic treated with high-dose sodium acetate. Diabetes was induced using streptozotocin. Sodium acetate was administered orally for a specified treatment period. At the end of the experiment, blood samples were collected for lipid profile analysis, including total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Results showed that diabetic rats exhibited significant increases in total cholesterol, triglycerides, and LDL-C, with a reduction in HDL-C compared with normal controls. Treatment with sodium acetate improved lipid parameters in a dose-dependent manner. The findings suggest that sodium acetate may possess beneficial effects against diabetes-induced dyslipidemia and could serve as a potential adjunct in the management of metabolic complications associated with diabetes.
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