EFFECT OF CEIBA PENTANDRA ON THE PANCREAS OF CADIUMINDUCED OXIDATIVE STRESS IN WISTER RAT
Abstract
Cadmium (Cd) is a widespread environmental pollutant with potent toxic effects, particularly
inducing oxidative stress, which can severely impair pancreatic function. Oxidative stress is linked
to various diseases, including diabetes, where the pancreas plays a critical role in insulin
production. This study investigates the protective effects of Ceiba pentandra (commonly known
as silk cotton tree), a plant renowned for its antioxidant and medicinal properties, on the pancreas
of Wistar rats subjected to cadmium-induced oxidative stress.
Twenty adult male Wistar rats were divided into four(4) groups: a control group, a cadmium-only
group (1000 mg/kg CdCl₂), and Two experimental groups pre-treated with low, and high doses of
Ceiba pentandra aqueous extract (400 and 800mg/kg body weight) following cadmium exposure.
Biochemical assays were conducted to measure oxidative stress markers, such as malondialdehyde
(MDA), glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT), while
histopathological studies were performed on pancreatic tissue to assess cellular damage and repair.
Results demonstrated that cadmium significantly elevated MDA levels, indicating lipid
peroxidation, and depleted antioxidant enzymes (SOD, GSH, and CAT) in the pancreas. However,
results are still yet to be released.
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