THE STUDY OF LEAD INDUCED HEPATOTOXIXITY IN A RAT MODEL. EVALUATING THE LEVELS OF LIVER DAMAGE.
Abstract
ABSTRACT
Lead exposure is a significant public health concern, and its toxicity can affect multiple organs including the liver. This study aimed to investigate the hepatotoxic effects of lead exposure in a rat model and evaluate the liver damage. Wistar rats were exposed to lead, orally, for 8 weeks, and liver function tests, histopathological examination were assessed. The results showed significant increase in liver enzymes (ALT, AST and ALP) in lead exposed rats compared to the control group. Histopathological examination revealed liver damage, including inflammation, necrosis, and sinusoidal congestion. Our findings suggest that lead exposure induces liver damage and oxidative stress in rats, which may have implications for human health. This study highlights the importance of monitoring liver function in individuals exposed to lead and exploring potential therapeutic strategies to mitigate lead- induced hepatotoxicity.
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