CHANGES IN KIDNEY FUNCTION PARAMETERS OF ALBINO RATS ASSOCIATED WITH SUB-CHRONIC ORAL ADMINISTRATION OF INFUSION OF ANTIMALARIAL POLYHERBAL TEA (PH-MF1)

ABSTRACT This study investigated the effects of a 7-day sub-chronic administration of an antimalarial polyherbal tea (MF1), formulated with black tea (Camellia sinensis), African locust bean (Parkia biglobosa), lemongrass (Cymbopogon citratus), and ginger (Zingiber officinale) in a 15:3:1:1 ratio, on kidney function parameters in albino rats. Twelve healthy albino rats (8–10 weeks old) were randomly assigned to four groups (n=3 per group). Group A (control) received water, Group B was administered a single dose of pyrimethamine-sulphadoxine, Group C received MF1 infusion, and Group D was given Lipton tea infusion, all orally via steel cannula for seven days. On day eight, blood samples were collected via ocular puncture for biochemical analysis of serum urea, creatinine, uric acid, and electrolytes using standard colorimetric methods. Results showed no significant differences in serum creatinine concentrations across all groups (p > 0.05), indicating preserved glomerular filtration. Group C exhibited a significant reduction in serum urea compared to Group A (p < 0.05), suggesting enhanced renal clearance, with no significant difference from Groups B and D (p > 0.05). Serum uric acid levels in Group C were significantly lower than in Group A and Group D (p < 0.05), but comparable to Group B (p > 0.05). Phytochemical analysis confirmed high levels of quercetin, kaempferol, and gingerol, supporting MF1’s antioxidant and nephroprotective properties. These findings suggest that MF1 does not impair renal function and may enhance renal clearance, supporting its potential as a safe malaria prophylactic option, though long-term studies are needed to confirm electrolyte safety.