ANTI-INFLAMMATORY PROPERTY OF ETHANOLIC EXTRACT OF MANGO (MANGIFERA INDICA) LEAF IN EXPERIMENTAL DIABETIC RATS
Abstract
This study evaluated the anti-inflammatory efficacy of ethanolic Mangifera indica (mango) leaf extract in streptozotocin (STZ)-induced diabetic male Wistar rats. Fresh leaves were collected in Offa, Nigeria, authenticated, air-dried, pulverized, and extracted via Soxhlet using 80% ethanol. The crude extract, standardized by GCMS for mangiferin (Kazeem et al., 2013), was administered orally at 150 mg/kg/day for 21 days. Twenty rats were randomized into four groups (n=5): normal control, diabetic control, metformin (150 mg/kg), and individual extracts (150 mg/kg each). Diabetes was induced with STZ (60 mg/kg i.p.); hyperglycemia (>200 mg/dL) confirmed inclusion. Serum IL-6 and TNF-α were quantified by ELISA post-sacrifice. Results showed significant elevation of both cytokines in diabetic controls (Pd.
Full-Text Access Notice
In accordance with the NERD Policy on promoting peer-reviewed publication, public access to the full text of a project, thesis or dissertation is restricted for three years, allowing the author and supervisors sufficient time to pursue peer-reviewed publication.
During this period, researchers with legitimate academic or research purposes may request authorisation directly from the author to enable NERD to release the indexed full texts of the work using the form below.