PHYTOCHEMICAL AND ANTI-BACTERIOLOGICAL ACTIVITY OF BITTER KOLA (GARCINIA KOLA) AGAINST SALMONELLA TYPHI
Abstract
This study investigated the phytochemical constituents and antibacterial activity of Bitter Kola (Garcinia kola) against Salmonella typhi, the causative organism of typhoid fever. Bitter kola has been widely used in traditional medicine for the treatment of various ailments due to its rich bioactive compounds. The seeds of Garcinia kola were collected, dried, pulverized, and extracted using ethanol and aqueous solvents. Standard phytochemical screening methods were employed to identify the presence of bioactive compounds, while the antibacterial activity was determined using the agar well diffusion method. The phytochemical analysis revealed the presence of alkaloids, flavonoids, tannins, saponins, phenols, glycosides, and steroids. The antibacterial assay showed that the extracts inhibited the growth of Salmonella typhi, with the ethanolic extract exhibiting a greater inhibitory effect than the aqueous extract. The study concluded that Garcinia kola possesses significant antibacterial properties against Salmonella typhi due to its phytochemical constituents and may serve as a potential source of natural antimicrobial agents. Further studies are recommended to isolate and characterize the active compounds responsible for the antibacterial activity.
Full-Text Access Notice
In accordance with the NERD Policy on promoting peer-reviewed publication, public access to the full text of a project, thesis or dissertation is restricted for three years, allowing the author and supervisors sufficient time to pursue peer-reviewed publication.
During this period, researchers with legitimate academic or research purposes may request authorisation directly from the author to enable NERD to release the indexed full texts of the work using the form below.