EFFECT OF JANECHUKS MIXED HERBAL SPECIES ON THE STOMACH OF A FEMALE ALBINO WISTAR RAT
Abstract
Herbal remedies are widely used in many parts of the world for their perceived therapeutic benefits, yet their safety and efficacy remain poorly understood. This study investigated the histological and physiological effects of Janechuks Mixed Spices (JCMS) a blend of ginger, garlic, cinnamon, and olive leaf on the stomach and body weight of female albino Wistar rats. Twenty (20) female Wistar rats were purchased, acclimatized for 14 days and were randomly assigned into four groups, control (2.5ml normal saline), low dose (2.5ml JCMS), moderate dose (5ml JCMS), and high dose (7.5ml JCMS), administered daily for 21 days. At the end of the experiment, the animals were sacrificed, stomach tissues were harvested, processed, and examined using hematoxylin and eosin staining, while changes in body weight were statistically analyzed. Histological findings revealed a clear dose-dependent response. Control (group A) showed normal gastric architecture, while the low-dose group (group B) displayed mild submucosal thickening consistent with early adaptive changes. The moderate-dose group (group C) exhibited widening of gastric pits and partial displacement of glands, suggesting structural distortion. At high doses (group D), severe alterations were observed, including pronounced pit spacing and marked glandular disorganization, reflecting significant mucosal injury. Body weight analysis showed that while all groups gained weight, rats treated with low doses recorded the greatest increase, whereas moderate and high doses attenuated weight gain, indicating a possible suppressive effect of higher concentrations. In conclusion, Janechuks Mixed Herbal Tea exerts both beneficial and adverse effects depending on the dose. Low concentrations appear relatively safe and may even support weight gain, while higher doses can compromise gastric integrity and growth. This dual action emphasizes the need for careful dose optimization and scientific validation before incorporating such herbal formulations into routine therapeutic or dietary use.
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