THE FORMULATION AND EVALUATION OF PHYSICO-MECHANICAL PROPERTIES OF PARACETAMOL TABLETS FORMULATED WITH CORN STARCH DERIVED PYRODEXTRIN (CSPD) AND POLYETHYLENE GLYCOL 1500 (PEG) 1500 CO GRANULATES
Abstract
The aim of this study is to formulate and evaluate the Physico-mechnical properties of
paracetamol tablets formulated using Corn starch-derived Pyrodextrin and polyethylene
glycol 1500 (PEG 1500) co-granulates. The cornstarch was heated in an oven at 121°c for 5
hours for pyrodextrinization to occur. On obtaining the dextrin, the dextrin was triturated in a
mortar with pellets of PEG 1500 to form granules. The co granules were formulated using
different ratio of concentrations of dextrin: PEG 1500 (0.5:1, 1:1, 1:2).Another set of co-
granules were produced using starch: PEG 1500 (0.5:1, 1:1, 1:2). Four different batches of
tablets were produced. Required quantities of various excipients were weighed and triturated
with CSDP-PEG 1500 co-granules in ratio 0.5:1, 1:1 and 2:1 as binders to produce batch A1,
A2 and A3 granules. While Corn starch (CS) - PEG 1500 co-granules in ratio 0.5:1, 1:1 and
2:1 as binders were used to produce batch B1, B2 and B3 granules. Dextrin alone and Starch
alone were used to produce batches C and D granules respectively. The granules were
characterized by measuring the flow properties and were compressed into tablets. Resultant
tablets were evaluated for hardness, friability, weight variability and disintegration tests.
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