THE AMELIORATIVE EFFECT OF FENUGREEK OIL ON THERMAL NOCICEPTION AND SUPEROXIDE DISMUTASE IN VINCRISTINE-INDUCED PERIPHERAL NEUROPATHY IN FRUIT FLIES
Abstract
Peripheral neuropathy (PN) is a debilitating condition often induced by chemotherapeutic agents such as vincristine, which disrupts microtubule function, leading to oxidative stress and neuroinflammation. Current treatments for vincristine-induced peripheral neuropathy (VIPN) are limited, necessitating exploration of alternative therapies. Fenugreek oil, derived from Trigonella foenum-graecum, exhibits antioxidant and neuroprotective properties, making it a promising candidate for mitigating VIPN. This study investigated the ameliorative effects of fenugreek oil on VIPN using Drosophila melanogaster as a model organism. Flies were exposed to vincristine (10 μM) and co-treated with fenugreek oil (10 mL) or gabapentin (25 mM). Behavioral assays (thermal nociception) and oxidative stress biomarkers (superoxide dismutase, SOD) were evaluated. Results demonstrated that fenugreek oil significantly improved thermal nociception latency (3.2 ± 1.4sec, 5.6 ± 1.9sec) and enhanced SOD activity (1.58 ± 0.09, 1.22 ± 0.14), indicating reduced oxidative stress. These findings suggest that fenugreek oil mitigates VIPN by modulating oxidative pathways and restoring sensory function, supporting its potential as a complementary therapy.
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