THE EFFECTS OF ACUTE AND CHRONIC INHALATION OF BODY SPRAY ON HAEMATOLOGICAL PARAMETERS OF WISTAR RATS
Abstract
This study investigated the impact of acute and chronic inhalation of body spray on haematological parameters of Wistar rats. The experiment aims to assess the potential health risks associated with prolonged exposure to commonly used body sprays. The research design involves three groups of 18 Wistar rats: one exposed to body spray for a short duration (acute) and another exposed over an extended period (chronic) and control group not exposed to body spray. Control group received normal rat chow daily. Acute exposed group ate normal rat chow daily and were exposed to inhaling body spray 3 days before the sacrificing day and the chronic exposed group also ate normal rat chow daily with exposure to inhaling body spray 4 weeks before the sacrificing day. Haematological parameters including; packed cell volume, red blood cell count, total white blood cell count, differential leucocyte count, platelet count, haemoglobin estimation and red cell indices, were measured at different time points. The results were then compared to a control group of rats that were not exposed to body spray. The study's findings contribute to our understanding of how inhalation of body spray might impact the blood composition of rodents, shedding light on potential implications for human health. This research holds significance in the context of public health and safety, as it provides valuable insights into the effects of common consumer products on haematological parameters. Statistically, there were no significant results in acute exposed Wistar rats when compared with control (p>0.05). Also, there were no statistically significant result in chronic exposed Wistar rats when compared with control (p>0.05).
Statistically on gender-based exposure: significant results were seen in red blood cell count, mean corpuscular haemoglobin concentration and packed cell volume in acutely exposed male Wistar rats when they were compared with the control group (p0.05). There were also significant results seen in red blood cell count and white blood cell count of chronic exposed male Wistar rats when compared with control group (p
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