EFFECTS OF ZINC CHLORIDE ON THE LIVER OF ADULT WISTAR RATS
Abstract
ABSTRACT
Zinc is an essential micronutrient required for numerous physiological processes, its excess intake or exposure can lead to hepatotoxicity. The hepatotoxic effects of zinc chloride have been documented in various animal models, yet comprehensive understanding of its impact on liver histology, function, and oxidative stress in Wistar rats remains limited. This study investigated the effects of zinc chloride on the liver of adult Wistar rats
Thirty two (32) healthy adult Wistar rats with body weight of 160-240 grams were divided into four (4) groups A, B, C and D with each group containing eight (8) animals. Group A rats were the control, while groups B, C and D were treated orally with zinc chloride at 5mg/kg, 10mg/kg and 20mg/kg for 28 days respectively. The rats were then sacrificed by cervical dislocation on the 29th days. The liver was removed and was immediately fixed in 10% formal saline. The tissue was processed and sectioned at 5µm and stained with hematoxylin and Eosin for histological study.
The results obtained from this study showed that the mean body weight of the Wistar rats decreased significantly (P0.05). The histological analysis of the liver showed different grades of cell distortion and disintegration of the cells of the liver across the treatment groups when compared to the photomicrograph obtained from the control group, which showed normal histoarchitecture.
This study then concludes that zinc chloride exposure is detrimental to the liver which may adversely affect the part function of the liver of adult Wistar rats.
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