INSILICO STUDIES, ANTIMICROBIAL SUSCEPTIBILITY, AND BACTERICIDAL ACTIVITY EVALUATION OF FLAVONOID DERIVATIVES AGAINST MRSA

Methicillin-resistant Staphylococcus aureus is one of the emerging public health concerns within the past two decades. It is a type of pathogenic Staphylococcus aureus, including those resistant to methicillin and other beta-lactam antibiotics (Lee et al., 2018). This, therefore, makes this microorganism really very tough to administer. This very dangerous super bacterium, as MRSA has come to be known due to its ability to resist many antibiotics, presents a great danger to public health and health systems from all over the world (López-Alcalde et al., 2015). The increasing trends of the prevalence of MRSA infections at healthcare facilities and in the community indicate that very effective preventive and control measures are needed. MRSA presents an enormous problem for public health. The most important thing is that MRSA infections become serious, even life- threatening in some patients, especially older adult, immunosuppressed and debilitated patients (Ray, 2017). In most cases, the pathogen causes a wide diversity in infections, ranging from minor skin and soft tissue infection to invasive diseases such as pneumoniae, bloodstream infections, and endocarditis.