ANTIBACTERIAL SUSCEPTIBILITY OF E. COLI ISOLATED FROM URINE SAMPLES IN SELECTED HOSPITALS IN OGUN STATE

The alarming increase of antibiotic resistance of Escherichia coli has posed a great challenge in the public sector. This study was aimed to investigate the antibacterial susceptibility of E. Coli isolated from urine samples in selected hospitals in Olabisi Onabanjo University Teaching Hospital (OOUTH) and Federal Medical Centre (FMC). Gram-negative Isolates were obtained from the laboratory of these selected hospitals, sub-cultured, Gram stained and were identified morphologically and biochemically as E. coli out of the other Gram-negative Isolates. The E. coli that carbapenem resistant were also documented. A total 204 Gram-negative isolates out of which 124 (60.8%) were obtained from OOUTH while 80 (39.2%) were obtained from FMC. A total of 48 (23.5%) E. coli were identified. Out of the 48, 12 (25%) E. coli were obtained from OOUTH while 36 (75%) were from FMC. The most resistant antibiotic was ciprofloxacin (100%) while the least resistant antibiotics were gentamicin and meropenem with 41.7% respectively. The total number of 43 (89.6%) E coli were resistant to carbapenems using disk diffusion. A total of 11 E coli identified from OOUTH were tested for carbapenem resistance using Modified Hodges Technique. One (9.1%) was positive while 10 were negative. Generally, E. coli had high resistance on the antibiotics. Ciprofloxacin was the most resistant while meropenem and gentamicin were the least resistant sensitive to E. coli.