EFFECT OF COMMON CAROTID ARTERY OCCLUSION (CCAO) ON WISTAR RATS AS A MODEL FOR ISCHEMIC STROKE: EVALUATING DIFFERENT OCCLUSION DURATIONS
Abstract
The study titled "Effect of Common Carotid Artery Occlusion (CCAO) on Wistar Rats as a Model for Ischemic Stroke: Evaluating Different Occlusion Durations" investigates the impact of varying durations of common carotid artery occlusion on ischemic stroke outcomes in Wistar rats. Ischemic stroke is a leading cause of mortality and disability globally, characterized by a sudden reduction in cerebral blood flow that results in neuronal injury or death. The CCAO model is widely utilized in ischemic stroke research due to its ability to replicate cerebral ischemia effectively, allowing for the examination of stroke mechanisms and potential therapeutic interventions. The primary aim of this research is to elucidate how different occlusion durations (5, 7, and 10 minutes) influence neuronal damage and recovery in Wistar rats. The study employs histological techniques, particularly Hematoxylin and Eosin (H&E) staining, to evaluate neuronal damage in brain tissues and analyze the relationship between occlusion duration and histological changes in critical brain regions, such as the cortex and striatum. Additionally, it investigates histopathological alterations like neuronal loss and white matter injury following the specified occlusion times. The significance of this research lies in its potential to bridge the gap between basic stroke research and clinical application. By clarifying how varying durations of ischemia affect both brain damage and functional impairments, the findings could inform clinical strategies for stroke management, ultimately leading to more effective treatments and improved outcomes for patients suffering from ischemic strokes. The study also aims to enhance the understanding of the pathophysiological processes involved in ischemic stroke, contributing valuable insights that may refine animal models used in preclinical research and improve their translation to human patients.
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